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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Matrix-Metallopeptidase 20</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_Matrix-Metallopeptidase_20" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">Matrix-Metallopeptidase 20
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<td colspan="3"><span typeof="mw:File"></span>
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<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2JSD">2JSD</a>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">376 Aminosäuren
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<td><a href="Koenzym" class="mw-redirect" title="Koenzym">Kofaktor</a>
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<td colspan="2" style="text-align:center;">2 Zn<sup>2+</sup>, Ca<sup>2+</sup>
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Name</a>
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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=7167">MMP20</a></i>
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<td>Externe IDs
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<td colspan="2" class="">
<ul><li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/604629">604629</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/O60882">O60882</a></li>
<li><a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="https://www.informatics.jax.org/marker/MGI:1353466">1353466</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Enzymklassifikation
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<td><a href="EC-Nummer" title="EC-Nummer">EC, Kategorie</a>
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<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.24.-">3.4.24.-</a>, <a href="Metalloprotease" class="mw-redirect" title="Metalloprotease">Metalloprotease</a>
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<td><a href="MEROPS" title="MEROPS">MEROPS</a>
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<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/merops/cgi-bin/pepsum?id=M10.019">M10.019</a>
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<td>Reaktionsart
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<td colspan="2" style="text-align:center;"><a href="Proteolyse" title="Proteolyse">Proteolyse</a>
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<td>Substrat
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<td colspan="2" style="text-align:center;">Amelogenin, Aggregan, COMP
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=O60882">MMP</a>
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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>
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<td colspan="2" style="text-align:center;"><a href="Eukaryoten" title="Eukaryoten">Eukaryoten</a>
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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
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<td style="background:#C3FDB8; color:#202122;">
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<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Maus
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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=9313&rn=1">9313</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=30800&rn=1">30800</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000137674;db=core">ENSG00000137674</a></small></small></span>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000018620;db=core">ENSMUSG00000018620</a></small></small></span>
</td></tr>
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<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/O60882">O60882</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q3LRH7">Q3LRH7</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004771">NM_004771</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_013903">NM_013903</a>
</td></tr>
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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004762">NP_004762</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_038931">NP_038931</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&position=chrchr11:101952776-102001273">Chr chr11: 101.95 – 102 Mb</a> </span>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks&position=chrchr9:7628240-7674979">Chr chr9: 7.63 – 7.67 Mb</a> </span>
</td></tr>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=9313">9313</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=30800">30800</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Matrix-Metallopeptidase 20</b> (Enamelysin), auch bekannt als <b>MMP20</b>, ist eine <a href="Peptidase" class="mw-redirect" title="Peptidase">Peptidase</a>, die in allen <a href="Eukaryoten" title="Eukaryoten">Eukaryoten</a> vorkommt und beim Menschen die Zahnproteine Amelogenin, <a href="Aggrecan" title="Aggrecan">Aggrecan</a> und COMP abbaut. <a href="Mutation" title="Mutation">Mutationen</a> im MMP20-<a href="Gen" title="Gen">Gen</a> können zur <a href="Amelogenesis_imperfecta" title="Amelogenesis imperfecta">Amelogenesis imperfecta</a> führen.<sup id="cite_ref-entrez_1-0" class="reference"><a href="#cite_note-entrez-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
</p><p>Die Proteine der Matrix Metalloproteinase (MMP) Familie sind am Aufschluss der <a href="Extrazellul%C3%A4re_Matrix" title="Extrazelluläre Matrix">extrazellulären Matrix</a> beteiligt und üben ihre Funktion bei zahlreichen physiologischen Prozessen aus, wie etwa im Rahmen von <a href="Embryonalentwicklung" class="mw-redirect" title="Embryonalentwicklung">Embryonalentwicklung</a>, Fortpflanzung, Gewebeumformung aber auch bei Krankheitsprozessen, wie der <a href="Arthritis" title="Arthritis">Arthritis</a> und bei der Tumormetastasierung. Die meisten MMP's werden als inaktive Proteinvorläufer aus der Zelle ausgeschleust und durch Spaltungsprozesse mittels extrazellulärer Proteinasen aktiviert. Das hier beschriebene Protein degradiert Amelogenin, das Hauptprotein der Zahnschmelzmatrix. Man vermutet deshalb, das es eine Rolle bei der <a href="Zahnschmelz" title="Zahnschmelz">Zahnschmelzbildung</a> spielt. Eine Mutation des Gens für MMP20, welche das normale <a href="Splei%C3%9Fen_(Biologie)" title="Spleißen (Biologie)">Splicing</a> der MMP20-mRNA stört und dazu führt, dass die <a href="Translation_(Biologie)" title="Translation (Biologie)">Translation</a> vorzeitig abgebrochen wird, wurde mit einer Form der <a href="Amelogenesis_imperfecta" title="Amelogenesis imperfecta">Amelogenesis imperfecta</a> in Verbindung gebracht. MMP20 gehört zu einer Gruppe eines Genclusters verschiedener MMP-Gene auf <a href="Chromosom_11" class="mw-redirect" title="Chromosom 11">Chromosom 11q</a>22.3.<sup id="cite_ref-entrez_1-1" class="reference"><a href="#cite_note-entrez-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>H. Nagase, J. F. Woessner: <i>Matrix metalloproteinases.</i> In: <i><a href="J._Biol._Chem." class="mw-redirect" title="J. Biol. Chem.">J. Biol. Chem.</a></i> vol. 274, Nr. 31, 1999, S. 21491–21494. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/10419448?dopt=Abstract">PMID 10419448</a></li>
<li>J. D. Bartlett, J. P. Simmer: <i>Proteinases in developing dental enamel.</i> In: <i>Crit. Rev. Oral Biol. Med.</i> vol. 10, Nr. 4, 2000, S. 425–441. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/10634581?dopt=Abstract">PMID 10634581</a></li>
<li>A. M. Pendás, I. Santamaría, M. V. Alvarez: <i>et al.</i> <i>Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.</i> In: <i>Genomics.</i> vol. 37, Nr. 2, 1997, S. 266–268. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8921407?dopt=Abstract">PMID 8921407</a></li>
<li>E. Llano, A. M. Pendás, V. Knäuper: <i>et al.</i> <i>Identification and structural and functional characterization of human enamelysin (MMP-20).</i> In: <i><a href="Biochemistry" title="Biochemistry">Biochemistry</a>.</i> vol. 36, Nr. 49, 1998, S. 15101–15108. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/9398237?dopt=Abstract">PMID 9398237</a></li>
<li>J. O. Stracke, A. J. Fosang, K. Last: <i>et al.</i> <i>Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).</i> In: <i><a href="FEBS_Lett" class="mw-redirect" title="FEBS Lett">FEBS Lett</a>.</i> vol. 478, Nr. 1–2, 2000, S. 52–56. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/10922468?dopt=Abstract">PMID 10922468</a></li>
<li>G. E. Terp, I. T. Christensen, F. S. Jørgensen: <i>Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.</i> In: <i>J. Biomol. Struct. Dyn.</i> vol. 17, Nr. 6, 2000, S. 933–946. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/10949161?dopt=Abstract">PMID 10949161</a></li>
<li>A. Väänänen, R. Srinivas, M. Parikka: <i>et al.</i> <i>Expression and regulation of MMP-20 in human tongue carcinoma cells.</i> In: <i>J. Dent. Res.</i> vol. 80, Nr. 10, 2001, S. 1884–1889. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11706946?dopt=Abstract">PMID 11706946</a></li>
<li>A. Väänänen, L. Tjäderhane, L. Eklund: <i>et al.</i> <i>Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors.</i> In: <i>Matrix Biol.</i> vol. 23, Nr. 3, 2005, S. 1531–1561. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/15296943?dopt=Abstract">PMID 15296943</a></li>
<li>J. W. Kim, J. P. Simmer, T. C. Hart: <i>et al.</i> <i>MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta.</i> In: <i>J. Med. Genet.</i> vol. 42, Nr. 3, 2006, S. 271–275. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/15744043?dopt=Abstract">PMID 15744043</a></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-entrez-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-entrez_1-0">a</a></sup> <sup><a href="#cite_ref-entrez_1-1">b</a></sup></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9313"><i>Entrez Gene: MMP20 matrix metallopeptidase 20 (enamelysin).</i></a><span class="Abrufdatum"> Abgerufen am 11. Januar 2011</span>.</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3AMatrix-Metallopeptidase+20&rft.title=Entrez+Gene%3A+MMP20+matrix+metallopeptidase+20+%28enamelysin%29&rft.description=Entrez+Gene%3A+MMP20+matrix+metallopeptidase+20+%28enamelysin%29&rft.identifier=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D9313"> </span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/O60882">O60882</a></span>
</li>
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